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Ann Thorac Surg 2001;71:1823-1824
© 2001 The Society of Thoracic Surgeons

Invited commentary

David S. Schrump, MDa

a Thoracic Oncology Section, Surgery Branch, National Cancer Institute, 10 Center Dr, Room 2B07, Bethesda, MD 20892-1502, USA

e-mail: david_schrump@nih.gov

Delivery of therapeutic agents via intratracheal administration is an attractive strategy for the treatment and prevention of aerodigestive tract cancers, as well as the prevention of ischemia-reperfusion injury and acute rejection following lung transplantation. Relative to viral delivery systems, naked plasmid vectors are markedly less efficient with regard to gene transfer to respiratory epithelia. However, plasmid vectors are easier and less costly to produce in large quantity, and are significantly less immunogenic than viral vectors; hence naked plasmid vectors may be utilized for repeated administration. Although presently not applicable for gene therapy of pulmonary neoplasms, naked plasma vectors expressing cytokines which function by paracrine mechanisms may be effective in attenuating the inflammatory processes associated with ischemia-reperfusion, or allograft rejection . . . [Full Text of this Article]


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Efficient naked plasmid cotransfection of lung grafts by extended lung/plasmid exposure time
Franco D’Ovidio, Niccolò Daddi, Takashi Suda, Kathleen Grapperhaus, and Alexander G. Patterson
Ann. Thorac. Surg. 2001 71: 1817-1823. [Abstract] [Full Text] [PDF]





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