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Ann Thorac Surg 2001;71:1650
© 2001 The Society of Thoracic Surgeons

Invited commentary

^a Department of Surgery, Nashville VA Medical Center, and Department of Cardiac and Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-5734, USA

This study poses an interesting question: Can the mature lung residual after pneumonectomy be induced to "grow" in a way that yields more functional lung parenchyma? The authors assess the efficacy of retinoic acid (RA), a Vitamin A metabolite, to stimulate parenchymal regeneration after pneumonectomy in a rodent model. In this model, the residual lung hypertrophies during the first 3 weeks after left pneumonectomy, yielding a 60% increase . . . [Full Text of this Article]

Related Article

Retinoic acid enhances lung growth after pneumonectomy

Aditya K. Kaza, Irving L. Kron, John A. Kern, Stewart M. Long, Steven M. Fiser, Richard P. Nguyen, Curtis G. Tribble, and Victor E. Laubach
Ann. Thorac. Surg. 2001 71: 1645-1650. [Abstract] [Full Text] [PDF]