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Ann Thorac Surg 2001;71:1650
© 2001 The Society of Thoracic Surgeons

Invited commentary

Richard N. Pierson, III, MDa

a Department of Surgery, Nashville VA Medical Center, and Department of Cardiac and Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-5734, USA

This study poses an interesting question: Can the mature lung residual after pneumonectomy be induced to "grow" in a way that yields more functional lung parenchyma? The authors assess the efficacy of retinoic acid (RA), a Vitamin A metabolite, to stimulate parenchymal regeneration after pneumonectomy in a rodent model. In this model, the residual lung hypertrophies during the first 3 weeks after left pneumonectomy, yielding a 60% increase . . . [Full Text of this Article]






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