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Ann Thorac Surg 2001;71:629-630
© 2001 The Society of Thoracic Surgeons

Invited commentary

Baiya Krishnadasan, MDa, Edward D. Verrier, MDa

a Division of Cardiothoracic Surgery, Box 356310, University of Washington, Seattle, WA 98195, USA

Organ preservation during transplantation provides a unique and potentially effective method for the use of viral vectors to attenuate reperfusion injury. Sakaguchi and coworkers have used a liposomal viral vector to target a specific cellular transcription factor, nuclear factor–kappa B (NF–{kappa}B). NF–{kappa}B is a central mediator in signal transduction pathways for inflammatory and hypoxic stress. Numerous investigators have demonstrated that blocking NF–{kappa}B favorably modulates ischemia–reperfusion injury. Hypothermia and circulatory arrest, both associated with organ preservation, may present a novel opportunity to block this central transcription factor using viral vectors.

There are some difficulties with the use of viral vectors . . . [Full Text of this Article]


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