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Ann Thorac Surg 2000;70:1530
© 2000 The Society of Thoracic Surgeons

Discussion

Discussion

Discussion

DR JOHN W. BROWN (Indianapolis, IN): First of all, this sounds almost too good to be true. Are there any side effects to the use of this drug? And number two, are there any planned clinical trials for the use of this drug in the treatment of pulmonary hypertension in the newborn?

DR DOMKOWSKI: Thank you, Dr Brown, for your comments and questions. To address your first question, there are no reported toxic side effects to bosentan as of yet in the literature, but it is still too early to know because it really has not been used chronically yet. So the answer to that question is, I just do not know because the data are not . . . [Full Text of this Article]






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