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Ann Thorac Surg 2000;69:434
© 2000 The Society of Thoracic Surgeons

Invited Commentaries

Ray C.-J. Chiu, MD, PhDa

a Division of Cardiothoracic Surgery, McGill University Health Center, 1650 Cedar Ave, Room C9-169, Montreal, PQ H3G 1A4, Canada

e-mail: mdiu@musica.mcgill.ca

Invited commentary

Heart failure is initiated by various primary injuries, such as valvular incompetence, myocardial infarction and cardiomyopathies. In response to impaired cardiac function associated with increased myocardial stress, an adaptation process known as ventricular remodelling takes place. Acutely, increased myocardial tension results in fiber stretching, which improves contractile force in accordance with Frank-Starling’s Law. However, chronic stretching induces synthesis of new sarcomeres in series, elongating fiber length and causing ventricular dilatation. This allows for the preservation of individual sarcomere length and function. Furthermore, with a larger heart, stroke . . . [Full Text of this Article]


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Composite cardiac binding in experimental heart failure
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Ann. Thorac. Surg. 2000 69: 429-434. [Abstract] [Full Text] [PDF]





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