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Ann Thorac Surg 2000;69:408
© 2000 The Society of Thoracic Surgeons


Invited Commentaries

Thomas M. Egan, MDa

a Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, 108 Burnett-Womack Building, CB #7065, Chapel Hill, NC 27599-7065, USA

Invited commentary

This study by Tanita and coworkers adds to a growing body of literature implicating activation of polymorphonuclear leukocytes (PMNs) as a contributing factor to pulmonary dysfunction. Using an isolated perfused rat lung model, the authors have investigated the impact of perfusion with human PMNs mechanically stimulated by gentle agitation in a glass vial. This resulted in increased CD18 integrin expression, assessed by immunofluorescence. The authors attempted to quantify capillary leak by modifying a method originally described by Aubrey Taylor’s group at the University of South Alabama. Capillary filtration coefficient has . . . [Full Text of this Article]


Related Article

Superoxide possibly produced in endothelial cells mediates the neutrophil-induced lung injury
Tatsuo Tanita, Chun Song, Hiroshi Kubo, Yasushi Hoshikawa, Shinsaku Ueda, and Shigefumi Fujimura
Ann. Thorac. Surg. 2000 69: 402-407. [Abstract] [Full Text] [PDF]






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