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Ann Thorac Surg 1999;68:2256-2257
© 1999 The Society of Thoracic Surgeons

Invited Commentaries

Thomas F. Slaughter, MDa

a Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA

e-mail: slaug003@mc.duke.edu

Invited commentary

In somewhat less than a decade, prophylactic administration of antifibrinolytic drugs has achieved such widespread acceptance that in some institutions, my own included, antifibrinolytic infusions during cardiac operations requiring cardiopulmonary bypass have become a "standard of care." This remarkable feat has occurred to a great extent in response to aprotinin. Pharmaceutical-sponsored efficacy trials of aprotinin have demonstrated significant reductions in blood loss and transfusion requirements. Unfortunately, as Casati and colleagues point out in their discussion, the costs associated with aprotinin therapy have led investigators to seek alternative, less costly antifibrinolytics for perioperative applications. In fact, . . . [Full Text of this Article]


Related Article

Hemostatic effects of aprotinin, tranexamic acid and {epsilon}-aminocaproic acid in primary cardiac surgery
Valter Casati, Davide Guzzon, Michele Oppizzi, Mariangelo Cossolini, Giorgio Torri, Giliola Calori, and Ottavio Alfieri
Ann. Thorac. Surg. 1999 68: 2252-2256. [Abstract] [Full Text] [PDF]





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Copyright © 1999 by The Society of Thoracic Surgeons.