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Ann Thorac Surg 1999;67:1630
© 1999 The Society of Thoracic Surgeons

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Invited Commentaries

^a Division of Cardiac Surgery, Department of Surgery, University of Leicester, The Glenfield Hospital, Groby Rd, Leicester LE3 9QP, United Kingdom

Invited commentary

The study by Kirsch and associates investigated whether the potassium channel opener cromakalim is cardioprotective in a rabbit model of brain death. In their study, hearts were explanted 90 minutes after the induction of brain death and then they were subjected to a prolonged period of hypothermic storage followed by 60 minutes of reperfusion in a crystalloid perfused isolated heart preparation. They used a bolus injection of a single dose of cromakalim as a substitute for ischemic preconditioning and showed that this has no significant protective effect in the presence or absence of brain death. Ischemic preconditioning is readily applied experimentally but may be cumbersome and difficult to use in clinical . . . [Full Text of this Article]

Related Article

Pretreatment with a potassium-channel opener before prolonged cardiac storage: an evaluation in an experimental brain death model

Matthias Kirsch, Sylvie Bertrand, Jean-Paul Garnier, Christine Fernandez, Christophe Baufreton, Alain Astier, and Daniel Loisance
Ann. Thorac. Surg. 1999 67: 1623-1629. [Abstract] [Full Text] [PDF]