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Ann Thorac Surg 1999;67:25-26
© 1999 The Society of Thoracic Surgeons

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Discussion

Discussion

DR EDWARD D. VERRIER (Seattle, WA): This brings me back to my 3 years in the laboratory of Julian Hoffman. Julian Hoffman was one of the foremost coronary blood flow physiologists of our era. This is a very difficult model, and the concept that you completely lose all autoregulation of coronary blood flow is a difficult concept. Normally, you can drop the coronary perfusion pressure of a dog or pig even down to about 40 mm Hg, and you maintain a constant flow (ie, autoregulate). At about 40 mm Hg, flow drops off, and the pressure–flow relation becomes linear. The curves that you show are at minimal resistance, so that pressure and flow follow when the pressure goes up or down. And that is a very difficult concept for a coronary blood flow physiologist to understand, and I think that the data would have to be very, very carefully looked at.

If it is true, it has implications, obviously, for the donor pool.

What is it that you . . . [Full Text of this Article]

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