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Ann Thorac Surg 1997;64:1387-1388
© 1997 The Society of Thoracic Surgeons

Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 1381.

DR WILLIAM A. BAUMGARTNER (Baltimore, MD): I congratulate you on a terrific study and for getting the leukocyte filters to work. We have had an interest in this for many years. In a clinical adult setting, we have never been able to reduce leukocytes to the level that I think you need to demonstrate a reduction in oxygen free radical release.

I have a couple questions. We saw that there was a correlation with a rise in white blood cell counts during filtration once rewarming took place. I wonder if you saw that in your clinical study?

Second, how long were your patients on bypass, and what were your mean bypass runs? Do you think that the reduction in white blood cells in your model was a result of the size of the patients, as opposed to some other mechanism?

My last question is, did you look at any other evidence that led to a decrease in the overall inflammatory state usually initiated by cardiopulmonary bypass, such as cytokine production or lung function, which at least experimentally has enjoyed a really beneficial effect of reducing the number of white blood cells? I enjoyed your paper very much.

DR ALLEN: Thank you for your comments. We are well aware of your previous work, and it helped stimulate our interest in this subject. The question of how to obtain low white blood cell counts in patients is an excellent one, and it is extensively addressed in the manuscript. We all recognize that leukocytes are deleterious, but because most filters are unable to effectively reduce the white blood cell count, . . . [Full Text of this Article]


Related Article

Detrimental Effects of Cardiopulmonary Bypass in Cyanotic Infants: Preventing the Reoxygenation Injury
Bradley S. Allen, Shaikh Rahman, Michel N. Ilbawi, Michael Kronon, Kirk S. Bolling, Ari O. Halldorsson, and Harold Feinberg
Ann. Thorac. Surg. 1997 64: 1381-1388. [Abstract] [Full Text]





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Copyright © 1997 by The Society of Thoracic Surgeons.