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Ann Thorac Surg 1997;63:1527-1528
© 1997 The Society of Thoracic Surgeons

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Editorial

Gene Transfer and Thoracic Surgery: More to Come

Division of Cardiothoracic Surgery, Department of Surgery, and Division of Pulmonary and Critical Care, Department of Medicine and the Thoracic Oncology Research Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

The first 20% of the full text of this article appears below.

The articles in this issue by Takeda and associates [1] and Boasquevisque and colleagues [2] focus on gene therapy, a topic that is relatively new to thoracic surgeons, but that likely will play a significant role in the future management of diseases of the chest. Using gene transfer to address problems encountered in lung transplantation is of particular interest because most of the work to date has targeted either inherited diseases such as cystic fibrosis, where the gene abnormality has been identified and the strategy is to replace the abnormal gene with the wild type (normal) gene, or malignant disease, where either gene replacement or introduction of novel genes has been attempted. These two articles present an interesting contrast in the use of gene transfer technology. One uses the power of this approach to create a model of human disease, whereas the other clearly is aimed at specific therapeutic interventions.

See also 1556 and 1562.

Gene transfer in intact organs proves to be feasible, and it remains for investigators to harness the true power and capabilities of this technology. The leap between observations in an animal model and clinical applications remains considerable, despite the fact that clinical trials of gene therapy are in progress. Both Takeda and associates [1] and Boasquevisque and colleagues [2] note the very low efficiency of gene transfer in their experimental models. Issues of gene . . . [Full Text of this Article]

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Ann. Thorac. Surg. 1997 63: 1556-1560. [Abstract] [Full Text]

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