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Ann Thorac Surg 1996;62:1465-1466
© 1996 The Society of Thoracic Surgeons

Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 1460.

DR THOMAS W. RICE (Cleveland, OH): This presentation addresses the timeless esophageal question: Which came first, the chicken or the egg? Do esophagogastric junctional carcinomas arise from gastric carcinomas originating in the cardia that eventually invade the esophagus or from esophageal carcinomas originating in the dysplastic Barrett's epithelium that eventually invade the stomach?

Iannettoni and associates found that two markers, p53 and SI, are found in similar proportions in both esophagogastric junctional carcinomas associated with Barrett's epithelium and those carcinomas that are not. Because these markers have been found in some patients with dysplastic Barrett's epithelium and Barrett's adenocarcinoma, this led Iannettoni and associates to propose that those carcinomas of the esophagogastric junction not associated with Barrett's epithelium, that express these markers, arose from Barrett's epithelium in which the specialized columnar lining cannot be detected at resection, therefore obscuring the origin of this subset of esophagogastric junctional carcinomas.

The problem with this argument is the assumption that p53 and SI are exclusive markers of Barrett's dysplasia and Barrett's adenocarcinoma. These markers . . . [Full Text of this Article]


Related Article

Detection of Barrett's Adenocarcinoma of the Gastric Cardia With Sucrase Isomaltase and p53
Mark D. Iannettoni, Stanley S. Lee, Mark R. Bonnell, Timothy L. Sell, Richard I. Whyte, Mark B. Orringer, and David G. Beer
Ann. Thorac. Surg. 1996 62: 1460-1465. [Abstract] [Full Text]





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