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Ann Thorac Surg 1996;62:796-797
© 1996 The Society of Thoracic Surgeons

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Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 791.

DR WALTER KLEPETKO (Vienna, Austria): Doctor Yamashita, I congratulate you on this well-designed, timely, and interesting study.

Nitric oxide has played an important role within the last years. Although its mechanism of acting is by far not completely understood, it has a tremendous potential and striking effects on pulmonary circulation and gas exchange as well. This has led to a widespread application of its inhaled form for treatment of patients with different forms of pulmonary insufficiency. The effects of nitroprusside administration you have shown us are striking as well, and improvement in oxygenation is far more impressive than has been demonstrated for almost any other substance that has been investigated in the field of lung transplantation.

I have a couple of questions addressing the use of intravenous nitroprusside in comparison with inhaled nitric oxide. First, how long does it take until nitroprusside administration results in effective increase of nitric oxide? Second, from the use of inhaled nitric oxide, . . . [Full Text of this Article]

Related Article

Nitroprusside Ameliorates Lung Allograft Reperfusion Injury

Motohiro Yamashita, Ralph A. Schmid, Koei Ando, Joel D. Cooper, and G. Alexander Patterson
Ann. Thorac. Surg. 1996 62: 791-796. [Abstract] [Full Text]