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Ann Thorac Surg 1996;62:38-39
© 1996 The Society of Thoracic Surgeons

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Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 31.

DR IRVIN KRUKENKAMP (Boston, MA): This was an excellent study! The blood-perfused rabbit Langendorff preparation is a very difficult model, and you are to be congratulated for bringing this study to fruition.

As you know, we presented our data using an intact sheep model at the American Heart Association meeting just a few months ago. We reported on the use of pinacidil in a cold blood cardioplegia model, and I note several differences of which I am sure you are aware.

We noticed that the time to either electrical or mechanical arrest was very quick, about 90 seconds, compared with your data of 4 minutes for mechanical arrest and 12 minutes for electrical arrest. I would be curious to hear your thoughts about this. In the cold cardioplegia study we noted 100% recovery of function compared with your data with a 69% functional recovery. Do you think the hearts in your study were "protected"? I . . . [Full Text of this Article]

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Myocardial Protection With Potassium-Channel Openers Is as Effective as St. Thomas' Solution in the Rabbit Heart

Jennifer S. Lawton, Jerry D. Sepic, Cynthia T. Allen, Peng-Wie Hsia, and Ralph J. Damiano, Jr
Ann. Thorac. Surg. 1996 62: 31-38. [Abstract] [Full Text]