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Ann Thorac Surg 1996;61:1135
© 1996 The Society of Thoracic Surgeons

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Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 1131.

DR SAFUH ATTAR (Baltimore, MD): I enjoyed Dr Katsaros' presentation regarding tranexamic acid in cardiac operations. I disagree with quite a few points. The first is that the basic study was done on patients who did not require any medication in the first place. Patients undergoing coronary artery bypass grafting for the first time very rarely require antifibrinolytic therapy, because the blood loss is minimal; it runs between 200 and 400 mL. So if you reduce it by 20% to 30%, you save 100 mL. I do not think that is really a reason to give tranexamic acid in coronary artery bypass grafting performed for the first time.

Now, the second thing is that you are treating bleeding, a complication, without knowing its cause. You do not treat pneumonia with antibiotics without knowing exactly the specific organism causing it, culturing it, determining its sensitivity to antibiotics, and then treating it. In these cases, we assume that . . . [Full Text of this Article]

Related Article

Tranexamic Acid Reduces Postbypass Blood Use: A Double-Blinded, Prospective, Randomized Study of 210 Patients

Demetrios Katsaros, Mark Petricevic, Norman J. Snow, Dennis D. Woodhall, and Robert Van Bergen
Ann. Thorac. Surg. 1996 61: 1131-1135. [Abstract] [Full Text]