Ann Thorac Surg 1996;61:1123-1124
© 1996 The Society of Thoracic Surgeons
Discussion
Discussion
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See also page 1118.
DR CURTIS G. TRIBBLE (Charlottesville, VA): This is a very interesting report, and it addresses a problem that many of us have faced over the years. It will certainly add to our armamentarium for dealing with patients with pulmonary hypertension or the need for two ventricular assist devices instead of one in settings of pulmonary hypertension. Perhaps this technique may even be useful in the setting of the lung transplantation with pulmonary hypertension.
We, at the University of Virginia, under the generation-long tutelage of the physiologist Dr Robert Berne, have a long devotion to adenosine. We have been taught to call it the ``Queen Metabolite.'' It seems like it affects almost every physiologic process in some positive way. We have looked at it in cardioplegia, in spinal cord protection, and in an effort to protect platelets during cardiopulmonary bypass. One of the things that we have learned is that adenosine has the beauty of being very short-acting, having a very short half-life. We also learned, however, that one of the potential disadvantages of adenosine infusions is that its metabolites are not nearly so short-lived and that these metabolites may be harmful.
So the questions that I would like to bring up are whether or not you had any opportunity to measure some . . . [Full Text of this Article]
Related Article
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Adenosine Effectively Controls Pulmonary Hypertension After Cardiac Operations
- David A. Fullerton, Stephen D. Jones, Frederick L. Grover, and Robert C. McIntyre, Jr
Ann. Thorac. Surg. 1996 61: 1118-1123.
[Abstract]
[Full Text]
Copyright © 1996 by The Society of Thoracic Surgeons.
