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Ann Thorac Surg 1996;61:40-41
© 1996 The Society of Thoracic Surgeons

Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 36.

DR GUO-WEI HE (Portland, OR): This has been a nice presentation. I have three questions for you. The first question is, what is the final concentration of endothelin-1 in the perfused blood after bolus injection, and is it clinically relevant? This is very important because we know that the plasma concentration of endothelin-1 is very low. Would you like to comment on the clinical relevance of your study?

The second question regards the source of endothelin-1 release. There are two sources to consider. First, after cardiopulmonary bypass, the elevated plasma concentration of endothelin-1 could be due to release from the systemic circulation. Second, as you hypothesized, endothelin-1 could be directly derived from the coronary circulation rather than from the systemic circulation. Your hypothesis is based on the second point, and I appreciate it. However, your results rejected this hypothesis because . . . [Full Text of this Article]


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Effects of Endothelin-1 and L-Arginine After Cold Ischemia in Lamb Hearts
Takeshi Hiramatsu, Joseph M. Forbess, Takuya Miura, Stephen J. Roth, Mark A. Cioffi, Mat, and John E. Mayer, Jr
Ann. Thorac. Surg. 1996 61: 36-40. [Abstract] [Full Text]



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