Ann Thorac Surg 1995;60:1020
© 1995 The Society of Thoracic Surgeons
Discussion
Discussion
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See also page 1015.
DR BRUCE A. REITZ (Stanford, CA): Doctor Pham should be congratulated for his presentation and Drs Griffith and Starzl for this very difficult clinical trial. They have demonstrated in their patients in these early results an increased incidence of microchimerism when compared with concurrent controls, and their hypothesis is that this chimerism will result in better long-term acceptance of the graft and perhaps a decrease in chronic rejection. Most previous work on bone marrow infusion at the time of transplantation has attempted to create donor-specific tolerance, perhaps an unacceptable or unobtainable clinical goal at the present time, but when bone marrow has been given it has usually been accompanied with some type of induction therapy, such as total lymphoid irradiation, whole body radiation, or antithymocyte globulin. My first question for Dr Pham is why . . . [Full Text of this Article]
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Perioperative Donor Bone Marrow Infusion Augments Chimerism in Heart and Lung Transplant Recipients
- Si M. Pham, Robert J. Keenan, Abdul S. Rao, Paulo A. Fontes, Robert L. Kormos, Kareem Abu-Elmagd, Adriana Zeevi, Akihiko Kawai, Brack G. Hattler, Robert L. Hardesty, Anthony J. Demetris, Massimo M. Trucco, Gayle L. Rosner, John J. Fung, Thomas E. Starzl, and Bartley P. Griffith
Ann. Thorac. Surg. 1995 60: 1015-1020.
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Copyright © 1995 by The Society of Thoracic Surgeons.