Ann Thorac Surg 1995;60:1014
© 1995 The Society of Thoracic Surgeons
Discussion
Discussion
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See also page 1008.
DR REPHAEL MOHR (Tel-Hashomer, Israel): In our experience we evaluated the effect of various stages of prebypass heparin administration and so on on platelet function with various methods, including in vitro, standard PLP aggregation, and whole blood aggregation, and we also evaluated it on the response of the blood from the patients to the extracellular matrix model as viewed by electron microscopy. In all those studies the initial platelet dysfunction observed was always after initiation of cardiopulmonary bypass and the levels of dysfunction were almost always observed when bypass temperature went down. However, whenever we measured the effect of heparin administration on platelet function with all these models, we never were able to demonstrate what you just showed us, that platelet function is in any way deranged by heparin administration. How can you explain this discrepancy?
DR KHURI: Other investigators, employing various methodologies, have also shown recently that heparin causes significant platelet dysfunction. In this study we have used a very reliable measure of in vivo platelet function, which is the ability of the platelet to produce thromboxane in response to a bleeding insult. I can only explain the discrepancy between our . . . [Full Text of this Article]
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Heparin Causes Platelet Dysfunction and Induces Fibrinolysis Before Cardiopulmonary Bypass
- Shukri F. Khuri, C. Robert Valeri, Joseph Loscalzo, Mark J. Weinstein, Vladimir Birjiniuk, Nancy A. Healey, Hollace MacGregor, Mheir Doursounian, and Michael A. Zolkewitz
Ann. Thorac. Surg. 1995 60: 1008-1014.
[Abstract]
[Full Text]
Copyright © 1995 by The Society of Thoracic Surgeons.
