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Ann Thorac Surg 1995;60:597-598
© 1995 The Society of Thoracic Surgeons

Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 593.

DR STEVEN J. MENTZER (Boston, MA): Doctor Smythe, the data you showed of the lac gene's staining of mesothelium suggested some tissue specificity. Before I would use the adenovirus vector in a patient, however, I would need significantly more evidence of tissue specificity. What evidence do you have that the virus is tropic for mesothelioma, and what explanation do you have for the mechanism of tumor elimination?

DR SMYTHE: There is absolutely no proof that it is specific for mesothelioma. We have shown in previous studies in addition to this that the adenovirus seems to be unable to traverse the mesothelial barrier in the chest and the peritoneal cavity. . . . [Full Text of this Article]






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Copyright © 1995 by The Society of Thoracic Surgeons.