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Ann Thorac Surg 1995;60:497-498
© 1995 The Society of Thoracic Surgeons

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Editorials

Molecular Biology 101

Department of Surgery, Medical College of Virginia, Richmond, Virginia

The first 20% of the full text of this article appears below.

In this issue of The Annals,Rowland and co-workers [1] call our attention to some of the strategies potentially useful for gene therapy. The concept of altering the control of cellular protein products through the process of gene manipulation is not new. The potential for clinical application of this strategy is, however, more realistic with every passing day.

Gene therapy is but one of the novel tools to emerge from the development of the branch of science termed molecular biology. Molecular biology is, in fact, a composite of two important pieces. The first of these is the collection of a series of biochemical techniques that facilitate understanding and manipulation of the genomic environment of the cell. The second component is conceptual. It changes our focus from primary manipulation of proteins by studying or manufacturing them exogenously and interacting with them (as with a monoclonal antibody), to an approach that manipulates cell proteins by using the nucleic acid base coding that is ultimately responsible for their production and degradation. In essence, this approach mimics . . . [Full Text of this Article]

Related Article

Potential Gene Therapy Strategies in the Treatment of Cardiovascular Disease

Robert T. Rowland, Joseph C. Cleveland, Jr, Xianzhong Meng, Alden H. Harken, and James M. Brown
Ann. Thorac. Surg. 1995 60: 721-728. [Abstract] [Full Text]

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