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Ann Thorac Surg 1995;60:306
© 1995 The Society of Thoracic Surgeons

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Discussion

Discussion

The first 20% of the full text of this article appears below.

See also page 300.

DR LESLIE HAMILTON (Newcastle-Upon-Tyne, United Kingdom): I am pleased to see that the search for the ``Holy Grail'' of a selective pulmonary vasodilator continues, and I congratulate Goldman and associates on what is obviously another step down this road. I do not have access to nitric oxide at the moment, so I am limited to prostacyclin, and you have demonstrated very well the difficulty with systemic hypotension. There have been some suggestions in the literature recently of giving prostacyclin via the endotracheal tube. Do you have any comments on that?

Second, I still have major concerns about the safety, both in the short term (although you have commented on that) and in the long term regarding the use of nitric oxide. Do you have any comments on toxicity, and do you feel comfortable recommending nitric oxide for prophylactic use in patients you would consider at high risk of pulmonary hypertension . . . [Full Text of this Article]

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Nitric Oxide Is Superior to Prostacyclin for Pulmonary Hypertension After Cardiac Operations

Allan P. Goldman, Ralph E. Delius, John E. Deanfield, and Duncan J. Macrae
Ann. Thorac. Surg. 1995 60: 300-305. [Abstract] [Full Text]