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Images in Cardiothoracic Surgery

Minocycline-Induced Pigmentation of the Aortic Valve and Sinuses of Valsalva

^a Department of Cardiac Surgery, The Royal Brompton and Harefield NHS Trust, London, United Kingdom
^b Department of Histopathology, The Royal Brompton and Harefield NHS Trust, London, United Kingdom

^_* Address correspondence to Dr Petrou, Department of Adult Cardiac Surgery, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom (Email: m.petrou@rhht.nhs.uk).

The first 20% of the full text of this article appears below.

A 63-year-old man with aortic regurgitation and a 6.0-cm ascending aortic aneurysm was referred for surgical repair. He was known to have chronic pulmonary aspergillosis, for which he was receiving long-term minocycline therapy. His medical history included primary hyperaldosteronism and Parkinson disease. The auricles of both ears were stained with a black pigment (Fig 1).

View larger version (116K):   Fig 1.