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Section of Cardiothoracic Surgery, The University of Chicago Medical Center, 5841 S. Maryland, Ste E-500, M/C 5040, Chicago, IL 60637
(Email: jraman1@uchicago.edu).
| The first 20% of the full text of this article appears below. |
Behind every promising therapy that fails to realize its potential is an interesting story. Ventricular containment is a concept first described by Power and Raman in 1997, but crept into publication in 1999 [1]. This entailed wrapping ventricles predisposed to progressive dilatation by a passive constraining mesh. The impetus to try this radical and presumably counter-to-conventional teaching approach was based on emerging data from the dynamic cardiomyoplasty experience.
The early animal experiments used strips of polyester mesh (usually mesh used for hernia repair) sutured together. We demonstrated proof of concept with customized modified polyester meshes, showing that this was a worthwhile approach early in the phase of ventricular dilatation [2]. However, the future of this approach was contingent on the development
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