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Ann Thorac Surg 2009;87:1523-1524. doi:10.1016/j.athoracsur.2009.03.051
© 2009 The Society of Thoracic Surgeons
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Original Articles: Pediatric Cardiac

Invited Commentary

Paul Modi, MD, FRCS, M. Saadeh Suleiman, DSc, PhD

Bristol Heart Institute, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom

(Email: paulmodi@doctors.org.uk).

The first 20% of the full text of this article appears below.

We read with interest the article by O'Brien and colleagues [1]. Many techniques of pediatric myocardial protection have been extrapolated from adult hearts, but due to the structural, functional and metabolic differences between immature and mature myocardium, this strategy does not stand up to scientific rigor. Cardioplegia should be tailored to the immature heart in the context of differences in age, cyanotic status, and pressure/volume overload, because all these variables influence the susceptibility to ischemia-reperfusion injury [2]. In fact, this is exactly why this area is so difficult to study in a clinical context.

Nonphysiologic increases . . . [Full Text of this Article]


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Ann. Thorac. Surg. 2009 87: 1517-1523. [Abstract] [Full Text] [PDF]





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