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Ann Thorac Surg 2009;87:868. doi:10.1016/j.athoracsur.2009.01.001
© 2009 The Society of Thoracic Surgeons
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Original Articles: General Thoracic

Invited Commentary

Stephen F. Badylak, DVM, PhD, MD, Thomas Gilbert, PhD

Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Dr, Suite 200, Pittsburgh, PA 15219

(Email: badylaks@upmc.edu; gilberttw@upmc.edu).

The first 20% of the full text of this article appears below.

Resection of tracheal tissue that spans more than approximately 6 cm in adults is not possible because of the lack of suitable artificial devices or replacement tissue that can perform the functions necessary to sustain life. An article by Seguin and colleagues [1] describes efforts to replace a 7-cm segment of the cervical trachea in a sheep model with the use of an aortic allograft; an approach that has been successfully used in a small number of selected human patients in France. Although the results of the present animal study are not entirely successful, the article does bring to the forefront some of the key issues that need to be addressed as the use of biologic tissue scaffolds for functional airway replacement receives increased attention. Based on the numerous failed efforts to replace . . . [Full Text of this Article]


Related Article

Tracheal Replacement With Cryopreserved, Decellularized, or Glutaraldehyde-Treated Aortic Allografts
Agathe Seguin, Dana Radu, Muriel Holder-Espinasse, Patrick Bruneval, Anne Fialaire-Legendre, Martine Duterque-Coquillaud, Alain Carpentier, and Emmanuel Martinod
Ann. Thorac. Surg. 2009 87: 861-867. [Abstract] [Full Text] [PDF]





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