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Department of Cardiothoracic Surgery, Drexel University College of Medicine, Philadelphia, PA 19102
(Email: marshall.jacobs@comcast.net).
| The first 20% of the full text of this article appears below. |
Nearly half a century has passed since Donald Ross' first report of homograft replacement of the aortic valve. Four years after that, he described the use of an aortic valved homograft as an extracardiac conduit to restore right ventricle-to-pulmonary artery continuity in the setting of pulmonary atresia. Currently, cryopreserved cadaveric aortic and pulmonary valved homografts are widely used in the reconstruction of congenital cardiac anomalies in infants, children, and adults.
Pulmonary valved homografts are used nearly exclusively to reconstruct the right ventricular outflow tract in the setting of pulmonary autograft replacement of the aortic valve. Homograft vascular patches are used to reconstruct aortic and pulmonary artery architecture in settings such as the Norwood procedures for hypoplastic left heart syndrome and related lesions. The use of cryopreserved homograft arterial tissue has been advocated to replace mycotic aneurysms and for other arterial
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