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Ann Thorac Surg 2008;86:1165-1166. doi:10.1016/j.athoracsur.2008.06.067
© 2008 The Society of Thoracic Surgeons
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Original Articles: Adult Cardiac

Invited Commentary

Mark Stafford-Smith, MD

Department of Anesthesiology, Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710

(Email: staff002@mc.duke.edu).

The first 20% of the full text of this article appears below.

Management guidelines for the perioperative angiotensin-converting enzyme inhibitors (ACEIs) are increasingly needed, as their use becomes more prevalent in patients presenting for cardiac surgery, and studies report experimental evidence for protective effects with short-term therapy with these agents. The ACEIs have their actions on the renin-angiotensin system (RAS), a signaling pathway that mediates systemic vasoconstriction, but has an equally important role in the local regulation of renal microcirculatory flow. Paradoxically, RAS blockade can . . . [Full Text of this Article]


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Umberto Benedetto, Sebastiano Sciarretta, Antonino Roscitano, Brenno Fiorani, Simone Refice, Emiliano Angeloni, and Riccardo Sinatra
Ann. Thorac. Surg. 2008 86: 1160-1165. [Abstract] [Full Text] [PDF]





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