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Ann Thorac Surg 2008;85:1503-1504. doi:10.1016/j.athoracsur.2007.10.049
© 2008 The Society of Thoracic Surgeons
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Correspondence

Proteasome Inhibitors in Myocardial Ischemia, Some Concerns

Saul R. Powell, PhD

The Feinstein Institute for Medical Research, The Albert Einstein School of Medicine, Department of Medicine, The Long Island Jewish Medical Center, 270-05 76th Ave, Room B-387, New Hyde Park, NY 11042

(Email: spowell@lij.edu).

The first 20% of the full text of this article appears below.

To the Editor:

I read with great interest the article by Stansfield and coworkers [1] that reports observations suggesting that pretreatment of mice with the proteasome inhibitor, PS-519, decreases postischemic infarct size and preserves cardiac function through a mechanism that might be linked to changes in nuclear factor kappa B (NF{kappa}B) signaling. Considering the critical role of the ubiquitin proteasome system in cardiac pathophysiology [2], this is an important study; however, certain issues with the experimental design, as well as interpretation of these studies require comment. There is concern that simply showing changes in I{kappa}B levels and phosphorylation of . . . [Full Text of this Article]


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William E. Stansfield and Craig H. Selzman
Ann. Thorac. Surg. 2008 85: 1504. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
S. R. Powell and A. Divald
The ubiquitin-proteasome system in myocardial ischaemia and preconditioning
Cardiovasc Res, January 15, 2010; 85(2): 303 - 311.
[Abstract] [Full Text] [PDF]

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 Ann. Thorac. Surg.Home page
W. E. Stansfield and C. H. Selzman
Reply
Ann. Thorac. Surg., April 1, 2008; 85(4): 1504 - 1504.
[Full Text] [PDF]


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