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Ann Thorac Surg 2008;85:694-695. doi:10.1016/j.athoracsur.2007.07.089
© 2008 The Society of Thoracic Surgeons

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Correspondence

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Shintaro Nemoto, MD, PhD

Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

(Email: snemoto@poh.osaka-med.ac.jp).

The first 20% of the full text of this article appears below.

To the Editor:

We appreciate the thoughtful comments of Drs Soueide and Rassi [1] regarding our article [2]. As pointed out [1], it is well recognized that cyclic guanosine monophosphate (cGMP) plays a clinically important role in maintaining pulmonary vascular tone (ie, pulmonary vasodilation, even immediately after cardiac surgery). Along with cGMP production therapy with inhaled nitric oxide for pulmonary hypertension [3], sildenafil has recently been recognized as an effective treatment option for various types of pulmonary hypertension and impaired pulmonary circulation [4, 5] by inhibiting degradation of cGMP. In fact, both inhaled nitrous oxide . . . [Full Text of this Article]


Related Article

Oral Sildenafil After Bidirectional Cavopulmonary Shunt
Tony Soueide and Issam Rassi
Ann. Thorac. Surg. 2008 85: 693-694. [Extract] [Full Text] [PDF]






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