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Ann Thorac Surg 2007;84:1164-1165
© 2007 The Society of Thoracic Surgeons
Division of Cardiothoracic Surgery, University of Mississippi Medical Center, 2500 N. State St, Jackson, MS 39216
(Email: lcreswell@surgery.umsmed.edu).
| The first 20% of the full text of this article appears below. |
Mariscalco and colleagues [1] report on the beneficial effect of preoperative administration of statin medications in reducing atrial fibrillation (AF) after coronary artery bypass grafting (CABG). This effect was preserved in a multivariate analysis that considered other pertinent preoperative and intraoperative variables.
The mechanisms responsible for postoperative AF are not completely understood, but may include ischemia, anatomic changes in the atrium, transient electrophysiologic and hemodynamic changes perioperatively, and inflammation, among others. These arrhythmias likely occur in patients at risk (eg, anatomical substrate) because of a perioperative trigger. The motivation for the
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Ann. Thorac. Surg. 2007 84: 1158-1164.
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