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Ann Thorac Surg 2007;84:108-109
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

Stephanie J. Brister, MD

Division of Cardiac Surgery, Department of Surgery, University of Toronto, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4

(Email: stephanie.brister@uhn.on.ca).

The first 20% of the full text of this article appears below.

Whitlock and colleagues [1] give us concrete evidence to back up clinical impressions of bleeding in cardiac surgical patients. The authors report a randomized, controlled trial of perioperative warfarin management in patients undergoing cardiopulmonary bypass (CPB). The aim of the study was threefold: (1) to describe the levels of vitamin K-dependent coagulation factor (VKDCF) in patients electively discontinuing warfarin who did or did not receive vitamin K, (2) to monitor the levels of VKDCF during and after CPB, and (3) to determine the residual anti-Xa activity after preoperative administration of a low molecular weight heparin (enoxaparin).

. . . [Full Text of this Article]


Related Article

Warfarin Cessation Before Cardiopulmonary Bypass: Lessons Learned from a Randomized Controlled Trial of Oral Vitamin K
Richard P. Whitlock, Mark A. Crowther, Theodore E. Warkentin, Mary-Helen Blackall, Forough Farrokhyar, and Kevin H.T. Teoh
Ann. Thorac. Surg. 2007 84: 103-108. [Abstract] [Full Text] [PDF]





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