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Ann Thorac Surg 2007;83:1922-1923
© 2007 The Society of Thoracic Surgeons

Correspondence

Are Cerebral Emboli Real When Perfluorocarbon Emulsion (AF0144) is Used in Cardiac Surgery?

Robert F. Mattrey, MD

Department of Radiology, University of California, 410 Dickinson St, San Diego, CA 92103

(Email: rmattrey@ucsd.edu).

The first 20% of the full text of this article appears below.

To the Editor:

As an investigator interested in the applications of perfluorocarbon (PFC) compounds in medicine, I note the article published by Hill and colleagues [1]. I suggest an alternate explanation for their reported increase in "cerebral emboli" that they observed in patients undergoing cardiopulmonary bypass (CBP) who received PFC emulsion instead of the control solution. They used an automated transcranial Doppler ultrasound device to detect emboli that is directly affected by the presence of PFC emulsion in blood, and they failed to control for this interference in their experimental design.

They were so convinced that these . . . [Full Text of this Article]


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Steven E. Hill and Hilary P. Grocott
Ann. Thorac. Surg. 2007 83: 1923. [Extract] [Full Text] [PDF]



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S. E. Hill and H. P. Grocott
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Ann. Thorac. Surg., May 1, 2007; 83(5): 1923 - 1923.
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