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Ann Thorac Surg 2007;83:1233-1234
© 2007 The Society of Thoracic Surgeons

Correspondence

Cell-Based VEGF Delivery Prevents Donor Cell Apoptosis After Transplantation

Lei Ye, MD, PhDa, Husnain Kh. Haider, MPharm, PhDb, Changfa Guo, MDc, Eugene K.W. Sim, FRCSd

a National University Medical Institutes, National University of Singapore, Singapore, 117597 Singapore
b Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529
c National University of Singapore, 10 Medical Dr, Singapore, 117597 Singapore
d Department of Surgery, National University of Singapore, Gleneagles JPMC Cardiac Center, Brunei Darussalam, Singapore, 117597 Singapore

(Email: yeleislp@hotmail.com; khhaider@hotmail.com; g0305832@nus.edu.sg; sursimkw@nus.edu.sg).

The first 20% of the full text of this article appears below.

To the Editor:

We read with interest the study by Yau and colleagues [1] that shows vascular endothelial growth factor enhanced survival of transfected skeletal myoblasts and heart cells in the cryo-injured rat heart [1].

The concept of using angiogenic genes to enhance the effects of cell transplant is not new. A combo-therapy approach based on cell and gene therapy improves blood vessel density in and around the infarcted myocardium and restores the left ventricular function of the injured myocardium through neomyogenesis [2–4]. We have shown that transplantation of . . . [Full Text of this Article]


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Terrence M. Yau, Angelo DeGasperis, and Lorenza DeGasperis
Ann. Thorac. Surg. 2007 83: 1234. [Extract] [Full Text] [PDF]



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