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Ann Thorac Surg 2007;83:1128
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

Steven Anderson, PhD

Physiology and Membrane Biology, University of California Davis, One Shields Ave, 4147A Tupper Hall, Davis, CA 95616-8644

(Email: seanderson@ucdavis.edu).

The first 20% of the full text of this article appears below.

The study by Wang and colleagues [1] demonstrates that when the Na/H exchange inhibitor cariporide and the ß-blocker metoprolol are given together prior to ischemia, infarct size is limited more than by cariporide alone. This result could become very important in improving treatments to limit ischemia/reperfusion (I/R) injury. However, because the model exposes the heart to exceedingly high left ventricular end-diastolic pressure (EDP), there may be problems extrapolating to clinical situations.

To reiterate, the model used by Wang and colleagues [1] and many others includes a water-filled left ventricular balloon that is filled to give a baseline EDP of 0 to 5 mm . . . [Full Text of this Article]


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Sodium–Hydrogen Exchange Inhibition and ß-Blockade Additively Decrease Infarct Size
Peipei Wang, Corinne Zaragoza, and William Holman
Ann. Thorac. Surg. 2007 83: 1121-1127. [Abstract] [Full Text] [PDF]





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