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Ann Thorac Surg 2007;83:1119-1120
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

Jun Feng, MD, PhD, Frank W. Sellke, MD

Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St, Lowry Medical Office Building, Suite 2A Boston, MA 02215

(Email: jfeng@caregroup.harvard.edu; fsellke@caregroup.harvard.edu).

The first 20% of the full text of this article appears below.

Yau and colleagues [1] report that the combination of bone marrow cell (BMC) transplantation with vascular endothelial growth factor/basic fibroblast growth factor (VEGF/bFGF) transgenes yields a synergistic effect on angiogeneisis in a rodent model of myocardial infarction. The authors found that mRNA of VEGF/bFGF was transiently expressed in BMC transfected with VEGF/bFGF transgenes, which leads to enhanced vascular density and improved regional perfusion and left ventricular contractile function. These novel findings suggest that multimodal cell-based gene therapy may be more useful in myocardial repair . . . [Full Text of this Article]


Related Article

Enhanced Angiogenesis With Multimodal Cell-Based Gene Therapy
Terrence M. Yau, Christopher Kim, Guangming Li, Yaoguang Zhang, Shafie Fazel, Dan Spiegelstein, Richard D. Weisel, and Ren-Ke Li
Ann. Thorac. Surg. 2007 83: 1110-1119. [Abstract] [Full Text] [PDF]





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