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Ann Thorac Surg 2007;83:725
© 2007 The Society of Thoracic Surgeons

Correspondence

Valproic Acid and Bleeding: Caution Required

John P. Veinot, MDa, Marc Ruel, MD, MPHb

a Pathology and Laboratory Medicine, University of Ottawa, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, K1Y 4E9 Canada
b Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7 Canada

(Email: jpveinot@ottawahospital.on.ca).

The first 20% of the full text of this article appears below.

To the Editor:

We read with interest the recent article proposing valproic acid as a neuroprotective agent for use in cardiac surgery 1]. The canine hypothermic circulatory arrest model demonstrated improved clinical, histologic, and biochemical measurements with pretreatment with this medication. Although this is promising, caution may be warranted for future human studies.

An association between valproic acid and increased surgical bleeding is well . . . [Full Text of this Article]


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Jason A. Williams and William A. Baumgartner
Ann. Thorac. Surg. 2007 83: 725-726. [Extract] [Full Text] [PDF]



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Ann. Thorac. Surg., February 1, 2007; 83(2): 725 - 726.
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