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Ann Thorac Surg 2007;83:214-215
© 2007 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Invited commentary

Giuseppe Pelosi, MDa, Juan Rosai, MDb

a Istituto Europeo di Oncologia (IEO), Via G Ripamonti 435, Milan, I-20141 Italy
b Centro Diagnostico Italiano (CDI), Via Saint Bon, 20, Milan, I-20147 Italy

(Email: giuseppe.pelosi@ieo.it; rosai@cdi.it).

The first 20% of the full text of this article appears below.

Pulmonary adenocarcinoma, the most prevalent subtype of lung cancer worldwide, can present in a variety of major morphological growth patterns (ie, acinar, papillary, solid with mucin, and bronchioloalveolar [BAC]), either in pure form or admixed. Several minor histologic variants also exist, such as fetal, mucinous, signet ring, and clear cell. The mixed subtypes, which make up approximately 80% of all resected cases, are morphologically heterogeneous neoplasms characterized by various combinations of histologic patterns, varying degrees of differentiation, different cell types, and variable cytological atypia, with each of these features often varying from field to field and from section to section in the same case. Therefore, rethinking lung adenocarcinoma according to a more dynamic and clinically relevant model is clearly warranted, keeping account of both tumor histogenesis (in turn related to the anatomical location) and prognostic and therapeutic implications. Within this frame of mind, dividing pulmonary adenocarcinomas into replacing (adenocarcinomas mixed with a BAC component, the latter . . . [Full Text of this Article]


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Ann. Thorac. Surg. 2007 83: 209-214. [Abstract] [Full Text] [PDF]





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