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Ann Thorac Surg 2007;83:160
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

Michael E. Jessen, MD

Department of Cardiovascular & Thoracic Surgery, University of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd Dallas, TX 75390-8879

(Email: michael.jessen@utsouthwestern.edu).

The first 20% of the full text of this article appears below.

Although infrequent, the occurrence of acute lung injury (ALI) after cardiopulmonary bypass (CPB) remains a serious problem. In this report, Wakayama and colleagues [1] describe the effect of Sivelestat (Ono Pharmaceutical Co. Ltd, Osaka, Japan), a neutrophil elastase inhibitor, on the development of ALI after exposure to lipopolysaccharide (LPS) and CPB. In a rabbit model, the combination of LPS and CPB led to an elevation in elastase activity and interleukin-8 levels, an accumulation of . . . [Full Text of this Article]


Related Article

Neutrophil Elastase Inhibitor, Sivelestat, Attenuates Acute Lung Injury After Cardiopulmonary Bypass in the Rabbit Endotoxemia Model
Fuminori Wakayama, Ikuo Fukuda, Yasuyuki Suzuki, and Norihiro Kondo
Ann. Thorac. Surg. 2007 83: 153-160. [Abstract] [Full Text] [PDF]





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