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Ann Thorac Surg 2006;82:2023
© 2006 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Invited commentary

David R. Jones, MD

Thoracic and Cardiovascular Surgery, University of Virginia, Lee St, 4th Floor, Suite 4823, Charlottesville, VA 22908-0679

(Email: djones@virginia.edu).

The first 20% of the full text of this article appears below.

Using a well-known lung ischemia-reperfusion animal model Shimamoto and colleagues [1] provided strong evidence that lung ischemia-reperfusion injury (IRI) is regulated through activation of the toll-like receptor 4 (TLR4). It is not surprising that this receptor is an important regulator of lung IRI, as it has already been demonstrated by this group, and others, to be involved in hepatic and cardiac IRI model systems. The observation that TLR4 deficient mice . . . [Full Text of this Article]


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Toll-Like Receptor 4 Mediates Lung Ischemia-Reperfusion Injury
Akira Shimamoto, Timothy H. Pohlman, Shin Shomura, Tomohito Tarukawa, Motoshi Takao, and Hideto Shimpo
Ann. Thorac. Surg. 2006 82: 2017-2023. [Abstract] [Full Text] [PDF]





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