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Ann Thorac Surg 2006;82:1575
© 2006 The Society of Thoracic Surgeons

Correspondence

Does the Combination of Aprotinin and Angiotensin-Converting Enzyme Inhibitor Cause Renal Failure After Cardiac Surgery?

David Royston, FRCA

Anesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Middlesex UB9 6JH United Kingdom

(Email: d.royston@rbht.nhs.uk).

The first 20% of the full text of this article appears below.

To the Editor:


Dr Royston discloses a financial relationship with Bayer HealthCare, GSK, Organon.

 

I would like to comment on the article by Kincaid and colleagues [1] suggesting an adverse interaction between aprotinin and inhibitors of angiotensin-converting enzyme inhibitor (ACEI).

First, the authors claim a "plausible mechanism" for their observations is induced by vasoconstriction of the efferent glomerular artery. A source reference is not cited. Studies thus far fail to show an effect of aprotinin on angiotensin-stimulated afferent or efferent artery . . . [Full Text of this Article]


Related Article

Reply
Edward H. Kincaid, Neal D. Kon, and John W. Hammon
Ann. Thorac. Surg. 2006 82: 1575-1576. [Extract] [Full Text] [PDF]



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E. H. Kincaid, N. D. Kon, and J. W. Hammon
Reply.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1575 - 1576.
[Full Text] [PDF]


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