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Ann Thorac Surg 2006;82:385-387
© 2006 The Society of Thoracic Surgeons


Editorial

Will Lung Volume Reduction Surgery Be Widely Applied?

Claude Lenfant, MD*

Former Director, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

* Address correspondence to Dr Lenfant, PO Box 83027, Gaithersburg, MD 20883 (Email: lenfantc@prodigy.net).

The first 300 words of the full text of this article appear below.

The article titled "Long-Term Follow-Up of Patients Receiving Lung-Volume-Reduction Surgery Versus Medical Therapy for Severe Emphysema" [1] published in this issue of The Annals of Thoracic Surgery is the latest in a series of papers by the National Emphysema Treatment Trial (NETT) Research Group. The first, published in 1999, introduced the rationale and design of the NETT [2]. In 2001, a publication [3] presented data from a well-defined group (69) of high-risk patients who were found to be unlikely to benefit from the surgery. Thereafter, patients meeting the criteria described in this publication were no longer recruited in the NETT. A 2003 paper [4] presented data from 608 surgical-therapy patients and 610 medical-therapy patients who had been followed for a median of 2.4 years [4], some for over 4 years. This paper also included data from the previously identified high-risk patient group [2]: after a median follow-up of 2.4 years, mortality rates in this high-risk group were 60% in surgical-therapy patients and 42.8% in medical-therapy patients (Table 1). The article included in this issue of The Annals reports on the same patients who were presented in the 2003 publication, but now with a median follow-up of 4.3 years, with some patients followed for over 7 years.


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Table 1. Comparison of the Death Rate by Therapy in all Subgroups
 
The goal of the NETT was primarily to assess the safety and efficacy of lung-volume–reduction surgery (LVRS) in comparison with medical therapy in patients with moderate-to-severe emphysema [2]. If safety and efficacy could be established, the next important goal was to identify patient selection criteria that would provide maximum efficacy. Efficacy was to be measured by mortality and maximal exercise capacity 2 years after randomization (actually, . . . [Full Text of this Article]


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Long-Term Follow-Up of Patients Receiving Lung-Volume-Reduction Surgery Versus Medical Therapy for Severe Emphysema by the National Emphysema Treatment Trial Research Group
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Ann. Thorac. Surg. 2006 82: 431-443. [Abstract] [Full Text] [PDF]



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