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Ann Thorac Surg 2006;82:109
© 2006 The Society of Thoracic Surgeons

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Original article: Cardiovascular

Invited commentary

University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB the Netherlands

(Email: y.j.gu@med.rug.nl).

The first 20% of the full text of this article appears below.

A systemic inflammatory response encountered during and after cardiopulmonary bypass turns to a severe postoperative immunosuppression in cardiac surgical patients, leading to a tendency of infection and multiorgan dysfunction. This is the current understanding of one of the most severe clinical scenarios of the adverse effects of cardiopulmonary bypass known as "whole body inflammatory response." In the past, particularly since the early 1980s, mounting evidence has suggested that patients who require cardiopulmonary bypass for cardiac operations are always associated with increased blood activation as a result of contact of blood with large scale nonphysiologic foreign surfaces. This heart-lung machine associated insult, together with the existence of surgical trauma and . . . [Full Text of this Article]