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Ann Thorac Surg 2006;81:927
© 2006 The Society of Thoracic Surgeons

Original article: Cardiovascular

Invited commentary

Richard L. Leask, PhD

Chemical Engineering, McGill University, 3610 University St, Montreal, QC, Canada H3A 2B2

(Email: richard.leask@mcgill.ca).

The first 20% of the full text of this article appears below.

Cryopreserved valve allografts offer superior hemodynamic performance in ventricular outflow reconstruction. Unfortunately, structural degeneration of the valve leaflets limits long-term durability. The performance and durability of any valve are dependent on the exquisitely complex tissue structure of the valve and annulus. Any disruption of the extracellular matrix structure will change the biomechanics of the tissue and may alter the function of any remaining viable cells.

Schenke-Layland and colleagues [1] have made a step forward in our understanding of the structural deterioration of cryopreserved tissue. . . . [Full Text of this Article]






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