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Ann Thorac Surg 2006;81:642
© 2006 The Society of Thoracic Surgeons


Original article: Cardiovascular

Invited commentary

Yoshifumi Naka, MD, PhD, Dmitri Belov, MD

Division of Surgery, Columbia University, Milstein Building, 177 Fort Washington Ave, New York, NY 310032

(Email: yn33@columbia.edu; db711@columbia.edu).

The first 20% of the full text of this article appears below.

This article by Boodhwani and colleagues [1] evaluates the possible mechanisms responsible for impairment of ischemia-induced angiogenesis by hypercholesterolemia. The single most important observation made in this report is that hypercholesterolemia directly impairs the balance of stimulatory and inhibitory factors of angiogenesis. The production of endostatin was significantly upregulated in the group with a high cholesterol level. . . . [Full Text of this Article]







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