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Ann Thorac Surg 2005;80:1260-1261
© 2005 The Society of Thoracic Surgeons

Original article: General thoracic

Invited commentary

R. Duane Davis, MD

Surgery/Division of Cardiothoracic Surgery, Duke University Medical Center, Box 3864, Trent Dr, Duke South, Rm 3543, Blue Zone, Durham, NC 27710

(Email: davis053@mc.duke.edu).

The first 20% of the full text of this article appears below.

Gastroesophageal reflux disease (GERD) has been demonstrated to be highly prevalent in patients with a variety of lung diseases, particularly patients with asthma, cystic fibrosis, and pulmonary fibrosis [1–3]. In a retrospective analysis of 458 patients undergoing lung transplantation at Duke, 74 patients had a 24-hour ambulatory pH probe study that was obtained pre-transplant of which 42 had abnormal studies (56.8%) and 158 patients had pH probe assessment post-transplant with 119 (74.9%) abnormal studies [4]. Of 37 recipients who had testing pre-transplant and post-transplant, 48.6% had abnormal pH studies pre-transplant, whereas 74.3% demonstrated abnormal pH studies post-transplant (paired t test; p = 0.005; odds ratio = 2.24). In addition, delayed gastric emptying was seen in 13.8% of patients pre-transplant and 38.2% post-transplant. Esophageal motility studies were abnormal in 28.6% of pre-transplant patients and 26.7% post-transplant. The findings of D'Ovidio and colleagues [5] that patients with end-stage lung disease . . . [Full Text of this Article]






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