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Giuliano Maggi
Enrico Ruffini
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Ann Thorac Surg 2005;79:1844
© 2005 The Society of Thoracic Surgeons

Original article: General thoracic

Invited commentary

Giuliano Maggi, MD, Enrico Ruffini, MD

Department of Thoracic Surgery, University of Torino, 3, Via Genova, Torino, 10126 Italy

(E-mail: giuliano.maggi@unito.it).

The first 20% of the full text of this article appears below.

Thymomas are rare mediastinal tumors that are encapsulated in approximately half the cases and invasive to the surrounding mediastinal structures in the remaining half. Thymomas are both chemo and radiosensitive neoplasms, which makes the possibility of a multimodal approach rather promising. Multimodality treatment in solid thoracic organ neoplasms has become the standard of care in locally advanced nonsmall cell lung cancer, Pancoast’s tumors, and recently in malignant pleural mesothelioma. The basic concept is attractive, ie, that chemotherapy is used as an induction therapy to downstage the tumor, which is possibly associated with radiotherapy to enhance the cytoreductive effect; surgery is used to remove all visible disease; postoperative radiotherapy is used to achieve maximal local control of the disease, which is eventually followed by consolidation chemotherapy to eradicate the microscopic disease responsible for late . . . [Full Text of this Article]






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