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Ann Thorac Surg 2005;79:1314-1315
© 2005 The Society of Thoracic Surgeons

Original articles: Cardiovascular

INVITED COMMENTARY

Eline F. Bruggemans, MSc, Anton van Boxtel, MSc, Hans A. Huysmans, MD, PhD

Department of Cardiothoracic Surgery, Leiden University Medical Center, Mathenesselaan 2, Oegstgeest 2343 HA, the Netherlandse.fbruggemans@lumc.nl

The first 20% of the full text of this article appears below.

Although serious neurologic sequelae after hypothermic circulatory arrest (HCA) have strongly declined due to increasing experience and improved cerebral protection strategies, there still exists a risk of long-term cognitive deficits that cannot reliably be detected with neuroimaging or routine neurologic examinations. Hagl and colleagues present a study on the feasibility of a porcine model of cognitive dysfunction after HCA. The effects of HCA on spatial learning and memory tasks were investigated using a multi-room maze. The clinical relevance of this model depends on the sensitivity of this behavioral measure to HCA and its relationship to human cognitive skills.

Studies in humans and animals suggest that . . . [Full Text of this Article]


Related Article

Use of a Maze to Detect Cognitive Dysfunction in a Porcine Model of Hypothermic Circulatory Arrest
Christian Hagl, Donald J. Weisz, Nawid Khaladj, Matthew M. Griepp, David Spielvogel, Bo-Yi Yang, Richard A. de Asla, Carol A. Bodian, and Randall B. Griepp
Ann. Thorac. Surg. 2005 79: 1307-1314. [Abstract] [Full Text] [PDF]





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