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Ann Thorac Surg 2004;78:1522
© 2004 The Society of Thoracic Surgeons

EDITORIAL

Clopidogrel and Postoperative Bleeding

Piet W. Boonstra, MD, PhDa,*, Wim van Oeveren, PhDb

a Department of Cardiothoracic Surgery, University Hospital of Groningen, Groningen, the Netherlands
b Department of Biomedical Engineering, Groningen University Medical Center, Groningen, the Netherlands

* Address reprint requests to Dr Boonstra, Department of Cardiothoracic Surgery, Groningen University Medical Center, Hanzeplein 1, 9713 EZ Groningen, the Netherlands (E-mail: p.w.boonstra@thorax.azg.nl).

The first 20% of the full text of this article appears below.

Clopidogrel,also known as Plavix, is an inhibitor of adenosine diphosphate–induced platelet aggregation (thienopyridine derivate). In combination with aspirin, which blocks the thromboxane-mediated pathway, it is recommended as the standard therapy for prevention of coronary artery stent thrombosis [1]. These two drugs ensure that platelet function will be inhibited and that stent thrombosis will be prevented. As a consequence of the widespread use of these drugs in treating acute coronary syndromes and using percutaneous coronary interventions, patients will have an increased risk of major bleeding [2]. In this issue of The Annals, Chu and associates prospectively assessed hemostasis after operations performed in 80 . . . [Full Text of this Article]




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 Br J AnaesthHome page
T. C. Collyer, D. J. Gray, R. Sandhu, J. Berridge, and G. Lyons
Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography(R) Platelet MappingTM
Br. J. Anaesth., April 1, 2009; 102(4): 492 - 498.
[Abstract] [Full Text] [PDF]


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