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Ann Thorac Surg 2004;78:388-389
© 2004 The Society of Thoracic Surgeons

Correspondence

Foscan-mediated photodynamic therapy and operation for malignant pleural mesothelioma: Reply

Joseph S. Friedberg, MD, Stephen M. Hahn, MD

Department of Radiation Oncology, Hospital of the University of Pennsylvania, 2 Donner, 3400 Spruce St, Philadelphia, PA 19104, USA

e-mail: hahn@xrt.upenn.edu

The first 20% of the full text of this article appears below.

To the Editor:

The major differences between the phase I/II study reported by Schouwink and associates [1] and our study [2] are the maximally tolerated dose of photodynamic therapy (PDT) (longer drug-light interval), the nature of the dose-limiting toxicity, and the use of parenchymal-sparing surgical intervention in a substantial number of patients in our study. We agree with Drs Schouwink and Baas that the different maximally tolerated dose of Foscan-mediated PDT achieved in our study is likely the result of our treating patients with an intact lung. In a subset of mesothelioma patients treated at the maximally tolerated dose of Foscan and light, our group [3] found a pattern of cytokine release after light illumination that could explain the . . . [Full Text of this Article]






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